Zoladex LA 10.8mg Injection
By Zoladex
Rx
1 Injection in a Prefilled syringe

Composition
Goserelin acetate(10.8mg)

Manufacturer - AstraZeneca
Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore

Expires on or after
July, 2025
About Zoladex LA 10.8mg Injection
Zoladex LA 10.8mg Injection contains Goserelin, which is part of a group of drugs known as Luteinising hormone-releasing hormone (LHRH) analogues. This medication is primarily used for treating prostate cancer in men, breast cancer, endometriosis, uterine fibroids, and infertility when used in combination with other medicines to regulate the release of eggs from the ovaries in women.
Goserelin, the active ingredient in Zoladex LA 10.8mg Injection, functions as a long-acting GnRH agonist, falling under the classification of Leutinizing hormone-releasing hormone (LHRH) agonists. LHRH agonists operate by suppressing the production of luteinizing hormone by the pituitary gland. This action triggers the testicles to release testosterone in men and induces the ovaries to release estrogen in women. It is important to note that this medication does not directly impact the cancer itself but operates solely on the testicles or ovaries. By reducing the levels of testosterone and estrogen, which are essential for the growth of testosterone or estrogen-dependent cancer cells, this medication helps inhibit cell growth in those cancer cells. In the case of prostate cancer, Zoladex LA 10.8mg Injection is commonly used alongside anti-androgen medications, which are substances designed to counteract the effects of testosterone.
Before beginning treatment with Zoladex LA 10.8mg Injection, it is crucial to inform your healthcare provider if you have any underlying liver, kidney, or heart conditions. This medication is not recommended for use in children, pregnant women, or breastfeeding mothers. Typically, the injection is administered subcutaneously (under the skin) on the stomach every four weeks (28 days) by a qualified medical professional. Common side effects of Zoladex LA 10.8mg Injection include hot flashes, sweating, decreased sex drive, and a reduction in bone density.
It is important to keep in mind that Zoladex LA 10.8mg Injection should be taken exactly as prescribed by your doctor, as incorrect usage or overdose can lead to severe side effects. It may take some time before the benefits of this medication are noticeable, so it is essential to continue treatment as directed by your healthcare provider. To mitigate the potential side effects on bone health, it is recommended to supplement with vitamin D and calcium while on this medication. Additionally, it is advised to disclose all other medications you are taking to your healthcare team, as interactions with other drugs may occur. It is crucial for both males and females undergoing treatment with Zoladex LA 10.8mg Injection to use effective contraception to prevent unintended pregnancy.
Benefits
When it comes to treating prostate cancer, Zoladex LA 10.8mg Injection offers several key benefits. Prostate cancer affects the prostate gland, a small walnut-sized gland in males responsible for producing seminal fluid to nourish and transport sperm. Often, one of the most common signs of prostate cancer is difficulty with urination. What makes Zoladex LA 10.8mg Injection unique is its ability to decrease or halt the growth of cancer cells by reducing the levels of testosterone, a natural hormone in males. By doing so, this medication helps alleviate the difficulty in passing urine, ultimately making it easier for individuals to urinate. This significant effect on reducing cancer cell growth and improving urinary symptoms highlights the valuable role that Zoladex LA 10.8mg Injection plays in the treatment of prostate cancer.
How to use the Zoladex LA 10.8mg Injection
When it comes to using Zoladex LA 10.8mg Injection, it is crucial to remember that only a healthcare professional should administer this medicine. It should not be self-administered. The injection will be given by your doctor or nurse under the skin on your stomach once every four weeks, which is equivalent to every 28 days. This injection schedule is important to follow for the medication to work effectively. By receiving the injection regularly as prescribed, you can ensure that you are getting the full benefits of Zoladex LA 10.8mg Injection in managing your condition. Remember to consult your healthcare provider if you have any questions or concerns about the usage of this medication.
Uses of Zoladex LA 10.8mg Injection
Zoladex LA 10.8mg Injection is commonly used to treat prostate cancer in men. Moreover, it is also used in the treatment of breast cancer, endometriosis, uterine fibroids, and infertility in women. This injection plays a crucial role in managing these health conditions and is prescribed by healthcare professionals to help alleviate symptoms and improve overall well-being.
What conditions Zoladex LA 10.8mg Injection treats?
Zoladex LA 10.8mg Injection is primarily used to treat prostate cancer in men. This type of cancer affects the prostate gland, which is responsible for producing seminal fluid that nourishes and transports sperm. Symptoms of prostate cancer often involve urination problems, but can sometimes be asymptomatic. This medication works by reducing testosterone levels in men, which in turn slows or stops the growth of cancer cells. By doing so, it can alleviate difficulties in urination commonly associated with prostate cancer.
Should you consult a doctor?
It is important to seek medical advice from your doctor if you have a history of high blood pressure, difficulties with urination and back issues, diabetes (in men), or osteoporosis before taking Zoladex LA 10.8mg Injection. These conditions may require careful monitoring or adjustments to your treatment plan. If you experience any new or worsening symptoms related to these conditions while using Zoladex LA 10.8mg Injection, it is crucial to consult your doctor promptly for further evaluation and guidance. Your doctor can provide personalized recommendations to ensure your health and well-being are maintained while undergoing treatment with Zoladex LA 10.8mg Injection.
Side effects of Zoladex LA 10.8mg Injection
Common side effects of Zoladex LA 10.8mg Injection may include bone weakness, injection site reactions such as pain, swelling, and redness, decreased libido, erectile dysfunction, depression, headache, dizziness, nausea, high blood pressure, breast atrophy, pain during sexual intercourse, hot flushes, sexual dysfunction, urinary tract disorders, lethargy, edema (swelling), upper respiratory tract infections, rash, sweating, decreased appetite, chronic obstructive pulmonary disease (COPD), heart failure, insomnia, vaginal inflammation, emotional lability, acne, breast enlargement, pelvic discomfort, application site reactions like burning, irritation, itching and redness, pain during periods, and uterine bleeding. Some individuals may also experience hot flushes and sweating, decreased sex drive, pain, bruising, bleeding, or redness at the injection site, thinning of bones, skin rashes, swelling and tenderness of breasts, impotence, lower back pain, difficulties passing urine, bone pain, reduced heart function, and increased blood sugar levels (in men). In women, side effects may include dryness of the vagina, acne, and headaches. Rash, itching, hives on the skin, swelling of the face, lips, tongue, or other body parts, wheezing, trouble breathing, and small cysts on the ovaries that can cause pain are less common but possible side effects. If you experience any of these side effects persistently or are concerned about them, it is important to consult your healthcare provider.
Safety advice

liver
Zoladex LA 10.8mg Injection is considered safe for use in patients with liver disease. It is reassuring to note that no dose adjustment of the medication is deemed necessary in such cases. This indicates that individuals with liver issues can typically use Zoladex LA 10.8mg Injection without concerns about the medication affecting their liver. It is always advisable to follow your healthcare provider's guidance when using this injection, especially if you have liver-related concerns.

kidney
Zoladex LA 10.8mg Injection is safe for use in patients with kidney disease. No dose adjustment is needed.

alcohol
When taking Zoladex LA 10.8mg Injection, be cautious about drinking alcohol. It is recommended to consult your doctor regarding alcohol consumption.

driving
Zoladex LA 10.8mg Injection typically does not impact your driving abilities.

pregnancy
Zoladex LA 10.8mg Injection is not safe to use during pregnancy. Studies on pregnant women and animals have shown harmful effects on the developing baby. It is recommended to consult your doctor regarding its use during pregnancy.

breastfeeding
Zoladex LA 10.8mg Injection is not safe for breastfeeding moms, as it could harm the baby due to potential toxicity.
Consumption warning before consuming Zoladex LA 10.8mg Injection
Before using Zoladex LA 10.8mg Injection for prostate cancer treatment, a healthcare professional must administer it via injection under the skin. Your doctor determines the appropriate dosage and frequency based on your condition. Adhering to your doctor's instructions is crucial to avoid severe side effects from improper use or overdose. Results may take weeks or months to manifest, so continue treatment unless advised otherwise.
Common side effects include hot flashes and injection site reactions like pain and swelling. Prolonged use may lead to weakened bones, so it's recommended to take vitamin D and calcium supplements concurrently. Inform your doctor if you have a history of alcoholism or diabetes. Additionally, disclose all medications to prevent potential interactions.
Avoid using Zoladex LA 10.8mg during pregnancy or breastfeeding, and both partners must use effective contraception to prevent pregnancy during treatment.
What if you forgot to take Zoladex LA 10.8mg Injection?
If you forget to take a dose of Zoladex LA 10.8mg Injection, it is important to seek guidance from your healthcare provider. It is crucial to stay on track with your treatment schedule to get the most benefit from the medication. Consulting your doctor promptly about a missed dose can help you decide on the best course of action to ensure the effectiveness of the treatment. Your doctor will be able to provide personalized advice and help you resume your treatment without interruptions.
Related lab tests
For monitoring patients receiving Zoladex LA 10.8mg Injection, several related lab tests are important. These include Prostate Specific Antigen (Free) PSA and Prostate Specific Antigen (Total) PSA. These tests are essential for evaluating the prostate health of male patients as Zoladex is commonly used in the treatment of prostate cancer. Monitoring PSA levels can help in assessing the response to treatment and detecting any potential recurrence of the cancer.
Additionally, Testosterone Total levels should be monitored regularly, especially in male patients, to assess the impact of Zoladex on testosterone levels. Anti Mullerian Hormone testing is crucial for female patients as Zoladex can affect ovarian function. Breast Cancer markers such as CA 15.3, along with Estrogen Receptor (ER) and Progesterone Receptor (PR) status testing, are important in female patients receiving Zoladex.
Moreover, monitoring Glycosylated Hemoglobin levels is essential, especially for patients with diabetes, as Zoladex may impact glucose metabolism. Thyroid Stimulating Hormone levels should also be monitored regularly to assess thyroid function, as hormonal treatments like Zoladex can potentially influence thyroid activity.
Regular monitoring of these related lab tests can help healthcare providers ensure the safety and effectiveness of treatment with Zoladex LA 10.8mg Injection in patients.
Additional Information
Habit Forming | No |
Chemical Class | GNRH Analogue |
Therapeutic Class | - |
Action Class | GNRH agonists/analogue |
FAQs
Disclaimer
The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.
₹28890
Inclusive of all taxes
Content verified by

Dr. Gowri Kulkarni
MBBS - General Medicine, DNB - Psychiatry, MRCGP [INT] Family Medicine, BSIC (BACP)
Last update on 01-Oct-2024