Velcade 1mg Injection

By Velcade

Rx

1 Injection in a Vial

Composition icon

Composition

Bortezomib(1mg)

Manufacturer - Janssen Pharmaceuticals icon

Manufacturer - Janssen Pharmaceuticals

Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060

Expires on or after icon

Expires on or after

July, 2025

About Velcade 1mg Injection

Velcade 1mg Injection is a medication used to treat multiple myeloma and mantle-cell lymphoma. It works by slowing down the growth of cancer cells in the body. This injection is administered by a healthcare professional, and the dosage will be determined by your doctor based on your condition. It is crucial to follow your doctor's instructions carefully to avoid serious side effects.

Common side effects of Velcade 1mg Injection may include fatigue, nausea, vomiting, and loss of appetite. It is important to stay hydrated during treatment and avoid activities that require alertness, as the medication can cause tiredness and dizziness. Regular blood tests are necessary to monitor blood cell levels and other vital parameters such as heart and liver health.

Before starting Velcade 1mg Injection, it is essential to inform your doctor about any existing liver, kidney, heart issues, or bleeding disorders. This medication may interact with other drugs, so it is crucial to disclose all medications you are taking to your healthcare provider. It is advised not to use Velcade 1mg Injection during pregnancy or while breastfeeding, and effective contraception is recommended during treatment.

Velcade 1mg Injection contains Bortezomib, classified as an Antineoplastic agent, and is used in adult patients for managing conditions like multiple myeloma and mantle-cell lymphoma in specific situations. Multiple myeloma affects plasma cells and presents symptoms such as bone pain and loss of appetite, while mantle-cell lymphoma affects the lymphatic system and may cause symptoms like fever and nausea.

Regular blood tests are recommended during treatment with Velcade 1mg Injection to monitor blood counts. This medication should not be used in patients with severe lung or heart disease. If you experience any unusual symptoms like dizziness, increased heartbeat, or muscle pain during or after treatment, inform your doctor immediately. Velcade 1mg Injection is not suitable for use in pregnant or breastfeeding women, children, or adolescents below the age of 18.


Benefits

Velcade 1mg Injection offers significant benefits for individuals with multiple myeloma and mantle-cell lymphoma. In multiple myeloma, this medication plays a crucial role in tackling the destructive bone processes by killing cancerous cells and preventing their further growth and spread in the body. By working alongside other cancer treatments like chemotherapy, Velcade increases the chances of survival for patients with multiple myeloma. Moreover, following the doctor’s instructions diligently can maximize the benefits of this treatment. Additionally, patients may receive supplements of calcium and Vitamin D3 to support their bone health if needed.

In mantle-cell lymphoma, Velcade 1mg Injection targets the cancerous white blood cells, known as non-Hodgkin's lymphoma, to inhibit their growth and stop the spread of cancer. This medication also interferes with certain chemicals essential for cancer progression. To enhance the effectiveness of the treatment, individuals are advised to take precautions such as avoiding crowded places, practicing frequent handwashing to prevent infections, and staying hydrated unless directed otherwise by their healthcare provider. By incorporating Velcade into the treatment plan and following the medical guidance provided, patients can experience improved outcomes and better manage their condition.


How to use the Velcade 1mg Injection

When using Velcade 1mg Injection, it is important to note that only a doctor or nurse should administer this medicine to you. It should not be self-administered. The injection will be given either into a vein as an intravenous infusion or into the skin as a subcutaneous injection. Your doctor will determine the appropriate dosage and duration of treatment based on factors such as your age, body weight, and the specific condition being treated. It is crucial to follow your doctor's instructions carefully and attend all scheduled appointments for your Velcade 1mg Injection treatment.


Uses of Velcade 1mg Injection

Velcade 1mg Injection is used in the treatment of multiple myeloma and mantle-cell lymphoma. In cases of progressive multiple myeloma where standard cancer treatments or stem cell transplantation are not options, Velcade can be used either alone or in combination with pegylated liposomal doxorubicin or dexamethasone. For untreated mantle-cell lymphoma, Velcade is prescribed with rituximab, cyclophosphamide, doxorubicin, and prednisone, especially when stem cell transplantation is not feasible for managing the condition.


What conditions Velcade 1mg Injection treats?

Velcade 1mg Injection is used to treat multiple myeloma and mantle-cell lymphoma. For multiple myeloma, it helps to kill cancer cells and prevent their further growth, which can weaken bones and cause pain. This medicine increases the survival rate when used in combination with other treatments like chemotherapy. In mantle-cell lymphoma, Velcade 1mg Injection restricts cancer growth by blocking certain chemicals needed for cancer to spread. It is important to follow your doctor's instructions carefully and stay hydrated to prevent infections.


Should you consult a doctor?

Before seeking Velcade 1mg Injection, contact your doctor if you have experienced any of these conditions such as low blood cell counts, bleeding issues, diarrhea, constipation, nausea, vomiting, fainting, dizziness, light-headedness, or neuropathy. It is crucial to inform your healthcare provider about preexisting conditions like blood pressure problems, seizures, shingles, and symptoms of tumor lysis syndrome including muscle cramping, weakness, confusion, visual disturbances, and breathing difficulties. Seek immediate medical attention if you notice signs of a serious brain infection like memory loss, difficulty walking, or vision loss, as well as muscle weakness, confusion, or seizures. Additionally, contact your doctor if you experience symptoms such as swelling, changes in heartbeat, high blood pressure, tiredness, or fainting, along with coughing, breathing difficulties, or chest tightness. Early medical intervention is essential for your well-being.


Side effects of Velcade 1mg Injection

Velcade 1mg Injection may cause several side effects. Common side effects like low blood platelets, fatigue, peripheral neuropathy (tingling and numbness in feet and hands), psychiatric disturbances, nausea, vomiting, loss of appetite, fever, anemia, and diarrhea may occur. Other potential side effects include decreased white blood cell count, constipation, inflammation of a vein, blood clots in veins and lungs, problems with blood clotting, insufficient circulation, and inflammation around the heart. Users may also experience bloody stools, cerebrovascular disorders, speech disorders, memory impairment, hearing loss, hormonal abnormalities, overactive thyroid gland, swelling of lymph glands, joint or muscle stiffness, pain in the groin, redness or pain at the injection site, and mouth pain.

In addition, users might encounter skin or tooth infections, genital pain, difficulty achieving an erection, weight gain, thirst, hepatitis, sepsis, skin reactions, bruises, falls, injuries, fluid retention, and sleep difficulties. Other potential side effects include confusion, dizziness, abnormal vision, chest discomfort, sweating, coughing, hiccups, difficulty swallowing, urinary tract infections, burning or tingling sensations, muscle or bone pain, and changes in blood pressure.

More severe side effects that require immediate attention include signs of neurological disorders like meningitis, Epstein-Barr virus infection, and peripheral neuropathy. Life-threatening conditions such as grade 4 neuropathy, autonomic neuropathy, progressive multifocal leukoencephalopathy, posterior reversible encephalopathy syndrome, cardiac failure, tumor lysis syndrome, and pulmonary hypertension can also occur. Furthermore, acute lung disorders, Guillain-Barre syndrome, allergic reactions, joint diseases, autoimmune disorders, and other serious complications may arise. Users should stop using Velcade 1mg Injection and consult their doctor if they experience any of the severe side effects mentioned.


Safety advice

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liver

When using Velcade 1mg Injection, it is important to be cautious if you have liver disease. Patients with liver issues may require a dose adjustment when using Velcade 1mg Injection. It is recommended to talk to your doctor before starting treatment to ensure the appropriate use of the medication.

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kidney

Velcade 1mg Injection should be used carefully in patients with severe kidney disease. Dose adjustment may be necessary. Limited information is available on its use in these patients. Please consult your doctor.

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alcohol

Velcade 1mg Injection may result in increased drowsiness when combined with alcohol.

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driving

Velcade 1mg Injection may cause side effects like tiredness, dizziness, fainting, or blurred vision, which could impact driving abilities.

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pregnancy

Velcade 1mg Injection is not safe to use during pregnancy due to the risk it poses to the developing baby. Only in life-threatening situations will a doctor consider prescribing it if the benefits outweigh the potential risks. Consult your doctor for advice.

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breastfeeding

Velcade 1mg Injection is not recommended for use during breastfeeding due to potential risks of toxicity to the baby. It is better to consult your doctor before using Velcade 1mg Injection.


Age above 75(Geriatrics)

Velcade 1mg Injection should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving Velcade 1mg Injection.

Age below 6 months(Pediatrics)

Velcade 1mg Injection is generally not recommended for use in children and adolescents (aged below 18 years). Consult your child’s doctor for advice before administering Velcade 1mg Injection to your child.

Consumption warning before consuming Velcade 1mg Injection

Before consuming Velcade 1mg Injection, it is crucial to follow the guidance provided by your doctor as the dosage and frequency will be determined by your medical professional based on your condition. Taking the medication incorrectly or in excess can lead to severe side effects. It may take some time before experiencing the benefits, so do not stop taking it unless advised by your doctor.

Common side effects such as fatigue, nausea, vomiting, and loss of appetite may occur, and it is recommended to stay hydrated during the treatment. Avoid driving or operating machinery due to potential dizziness or tiredness caused by the medication. Regular blood tests are necessary to monitor blood cell levels and other vital parameters.

Inform your doctor if you have liver, kidney, heart issues, or bleeding problems before starting treatment. If you notice memory loss or cognitive difficulties, seek medical advice promptly. Discuss all medications you are taking with your healthcare team as interactions may occur. Velcade 1mg Injection is not recommended during pregnancy or breastfeeding, and effective contraception should be used to prevent pregnancy.


What if you forgot to take Velcade 1mg Injection?

If you forget to take a dose of Velcade 1mg Injection, it is important to speak with your doctor promptly. It's crucial to follow your prescribed treatment schedule closely to ensure the effectiveness of your medication. Contacting your healthcare provider will allow them to provide guidance on how to proceed if you have missed a dose. It is not recommended to try to make up for missed doses on your own. Your doctor will be able to advise you on the best course of action to maintain the appropriate treatment plan for your condition.


What happens if you take overdose of Velcade 1mg Injection?

Overdose of Velcade 1mg Injection is unlikely to occur because it is administered only by healthcare professionals in a hospital setting. Nevertheless, if you notice any unusual symptoms such as sudden low blood pressure when standing up or a decrease in platelet count, you should promptly inform your doctor. These signs could indicate a potential issue that needs medical attention. It is essential to be aware of any changes you experience after receiving Velcade 1mg Injection and to seek help if needed.


Related lab tests

For patients receiving Velcade 1mg Injection, certain lab tests are important to monitor their health and response to treatment. These tests include Albumin/Globulin Ratio, Serum, which helps assess liver and kidney function, as well as protein levels in the blood. Another crucial test is the Complete Blood Count, which gives information about red and white blood cell levels, hemoglobin, and platelets. Additionally, the Kidney Function Test is essential to evaluate how well the kidneys are working and how they might be affected by the medication. Monitoring these lab tests can provide valuable insights into the patient's overall health and help healthcare providers make informed decisions regarding their treatment.


Additional Information

Habit FormingNo
Chemical ClassPhenylalanine Derivative
Therapeutic Class-
Action ClassProteasome inhibitor

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Disclaimer

The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Upasana Bhatia

MBBS - General Medicine

Last update on 11-Feb-2025