Tasigna 150mg Capsule

By Tasigna

Rx

4 Capsule in a Strip

Composition icon

Composition

Nilotinib(150mg)

Manufacturer - Novartis India Ltd icon

Manufacturer - Novartis India Ltd

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India

Expires on or after icon

Expires on or after

April, 2026

About Tasigna 150mg Capsule

Tasigna 150mg Capsule is a medication used in the treatment of blood cancer, specifically chronic myeloid leukaemia. It is meant for patients whose condition has not responded to other leukaemia treatments or who experience intolerable side effects from other medications. The capsule should be taken on an empty stomach at the same time daily as prescribed by the doctor. The dosage and frequency will vary depending on the individual's treatment needs and may change over time. It is crucial to follow the doctor's instructions precisely to avoid serious side effects.

Common side effects of Tasigna 150mg Capsule include headaches, nausea, abdominal pain, and rash. If severe diarrhea occurs, it is recommended to consult a doctor or increase fluid intake during treatment. This medication may lower blood cell counts, making the body more prone to infections, requiring regular blood tests to monitor levels. Prior to starting treatment, inform your doctor about any existing heart, liver, or kidney conditions, as well as current medications to prevent interactions. Tasigna 150mg Capsule is not advised during pregnancy or breastfeeding, and effective contraception is essential for both genders during treatment.

Tasigna 150mg Capsule falls under the category of tyrosine kinase inhibitors, a type of anticancer drug used specifically against Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). This type of blood cancer alters the behavior of white blood cells. The capsule contains Nilotinib, which targets and blocks the abnormal Bcr-Abl tyrosine kinase protein that signals cancerous white blood cells to multiply. By inhibiting cell growth and promoting cell death, Tasigna 150mg Capsule aids in combating cancer. Usage should align with the doctor's recommendations based on individual medical conditions, and common side effects like vomiting, nausea, and fatigue typically diminish over time.

Patients allergic to Nilotinib or similar medications should inform their doctor to avoid adverse reactions. Pregnant or breastfeeding individuals should not take Tasigna 150mg Capsule, and reliable contraception is essential during treatment and two weeks post-treatment. Not recommended for children under one year of age, individuals taking this medication should be cautious while driving due to potential side effects like dizziness or vision impairment. Alert your doctor if any symptoms of liver issues such as yellowing skin, dark urine, or stomach pain occur during Tasigna 150mg Capsule usage.


Benefits

Tasigna 150mg Capsule, containing the active ingredient Nilotinib, offers several therapeutic benefits for patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). In individuals with this type of blood cancer, a genetic change triggers the body to overproduce abnormal white blood cells, leading to the development of cancerous cells. Nilotinib, the key component of Tasigna, works by blocking this harmful signal, effectively halting the production of these cancerous cells.

One of the significant benefits of Tasigna is its ability to kill existing cancer cells and hinder the growth of new ones. By interfering with the signal that promotes the abnormal white blood cell production, this potent medication helps to reduce the progression of the disease and improve the body's ability to fight the cancer. Tasigna is particularly valuable for patients who have been newly diagnosed with Ph+ CML in the chronic phase, as well as for those in the accelerated and chronic phases who have not responded well to other treatment options like Imatinib.

It is essential to note that Tasigna is a robust and potentially toxic medicine, underscoring the importance of discussing its risks and benefits thoroughly with your healthcare provider. Despite its potency, Tasigna can offer a valuable therapeutic option for individuals with Ph+ CML who may not have responded adequately to previous treatments. Additionally, during the course of Tasigna treatment, it is advised to refrain from consuming alcohol and ensure proper hydration by drinking plenty of water to support overall health and well-being.

In conclusion, Tasigna 150mg Capsule provides a targeted approach to treating Ph+ CML by addressing the underlying genetic trigger and disrupting the production of cancerous cells. Its effectiveness in controlling disease progression and improving outcomes for patients with challenging forms of CML highlights its importance as a valuable treatment option in the management of this blood cancer.


How to use the Tasigna 150mg Capsule

To use Tasigna 150mg Capsule, it is essential to follow the instructions provided by your doctor strictly. This medication should be taken on an empty stomach, meaning you should not eat any food at least 2 hours before taking the capsule and wait at least 1 hour after taking it before eating again. The capsule should be swallowed whole with a glass of water. In case you have difficulty swallowing the capsule, you can open it and sprinkle the contents in 1 teaspoon of applesauce. It's important to take it immediately within 15 minutes after mixing it with applesauce. Remember not to use more than one teaspoon of applesauce for each capsule, and do not substitute it with any other food. Following these guidelines will help ensure the effectiveness of Tasigna 150mg Capsule in your treatment.


Uses of Tasigna 150mg Capsule

Tasigna 150mg Capsule is used in the treatment of blood cancer, specifically in individuals diagnosed with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). This medication is essential in managing this type of leukemia by targeting and inhibiting the growth of cancerous cells with the specific Philadelphia chromosome mutation. By blocking the activity of certain proteins caused by this genetic abnormality, Tasigna 150mg Capsule helps to slow down the progression of the disease and improve the patient's overall condition. It is crucial to follow the prescribed dosage and instructions provided by healthcare professionals for maximum effectiveness in the treatment of Ph+ CML.


What conditions Tasigna 150mg Capsule treats?

Tasigna 150mg Capsule is used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), a type of blood cancer where specific chromosomes swap positions, leading to the production of abnormal white blood cells in the bone marrow. The abnormality creates the Philadelphia chromosome, which produces an abnormal protein triggering the abnormal cell growth. Symptoms may include weight loss, weakness, night sweats, fatigue, feeling full quickly, bone pain, and easy bruising. Many individuals may not show symptoms before diagnosis.


Should you consult a doctor?

If you are taking Tasigna 150mg Capsule, there are certain circumstances when you should seek medical attention. If you experience severe diarrhea, it is important to consult your doctor or ensure you are drinking enough fluids during treatment. Additionally, if you notice any persistent or worrying side effects such as severe headache, nausea, abdominal pain, or rash, it is recommended to reach out to your healthcare provider for guidance. Since this medication may lead to a decrease in blood cell count, causing increased susceptibility to infections, it is crucial to stay vigilant for any signs of infection and inform your doctor promptly. Regular blood tests are necessary to monitor your blood cells, heart, liver, and other levels in the body. Furthermore, if you have pre-existing conditions like heart disease, liver, or kidney problems, or if you are on other medications, it is essential to consult with your doctor before starting Tasigna. In case of any concerns or uncertainties about the medication or its side effects, it is advisable to seek medical advice promptly.


Side effects of Tasigna 150mg Capsule

When taking Tasigna 150mg Capsule, you may experience certain side effects. These can include headaches, nausea, abdominal pain, rash, itching, hair loss, muscle pain, and fatigue. Some people also report vomiting, diarrhea, constipation, tiredness, and muscle and joint pain. Most of these side effects are temporary and should lessen as your body gets used to the medication. However, if these side effects persist or cause concern, it is important to consult your doctor for advice and further guidance.


Safety advice

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liver

Individuals with liver disease should exercise caution when using Tasigna 150mg Capsule. It may be necessary to adjust the dosage of the medication in these cases. It is essential to consult with your doctor regarding the use of Tasigna 150mg Capsule if you have liver disease.

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kidney

Limited data shows Tasigna 150mg Capsule is likely safe for kidney patients; dose adjustment may not be required. Consult your doctor for guidance before use.

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alcohol

When taking Tasigna 150mg Capsule, it is safe to drink alcohol as it does not result in harmful side effects.

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driving

Tasigna 150mg Capsule may reduce alertness, affect vision, cause sleepiness, and dizziness. Avoid driving if experiencing these effects.

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pregnancy

Tasigna 150mg Capsule should not be used during pregnancy due to the risk it poses to the developing baby. However, in rare life-threatening cases, a doctor may prescribe it if benefits outweigh risks. Consult your doctor for further guidance.

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breastfeeding

Tasigna 150mg Capsule is not safe to use while breastfeeding. There is a risk of the drug causing harm to the baby.


Consumption warning before consuming Tasigna 150mg Capsule

Before consuming Tasigna 150mg Capsule, it's crucial to note several important warnings. Firstly, inform your doctor if you are allergic to Nilotinib or any other medications. Avoid taking Tasigna if you are pregnant or breastfeeding. When using this medication, make sure to use effective contraceptive methods and continue for two weeks after completing the course. Tasigna is not suitable for children under one year old, and it may impact the growth and development of children with chronic phase Ph+ CML. Watch for slower growth in children and adolescents while using Tasigna. Be cautious while driving, as Tasigna can cause dizziness or visual disturbances. This medication may also increase the risk of liver problems, especially in individuals with a history of liver issues. Look out for symptoms such as yellowing of the skin and eyes, dark urine, or stomach pain, which could indicate liver problems. Inform your doctor of any severe lactose or sugar intolerance, as Tasigna may contain lactose. Avoid Tasigna if you have low levels of magnesium or potassium in the blood or a history of long QTc syndrome. If you've had a total gastrectomy, consult your doctor before taking Tasigna 150mg Capsule.


What if you forgot to take Tasigna 150mg Capsule?

If you forget to take your scheduled dose of Tasigna 150mg Capsule, it is important not to take an extra dose to make up for the missed one. Simply skip the missed dose and continue with your regular dosing schedule. Taking a double dose is not recommended and may increase the risk of experiencing side effects. Remember to follow your prescribed treatment plan closely to get the most benefit from your medication.


Related lab tests

Related Lab Tests for monitoring patients taking Tasigna 150mg Capsule include tests to evaluate the effectiveness of the medication and its impact on the body.

Bcr-Abl Gene Translocation (Qualitative) and Bcr-Abl Gene Translocation (Quantitative) are crucial tests to assess the presence and quantity of this specific gene change associated with certain types of leukemia. These tests help determine if Tasigna is effectively targeting the Bcr-Abl gene and inhibiting its activity.

Monitoring the impact on blood counts is important, and thus a Complete Blood Count (CBC) is recommended. This test provides information on the levels of different blood cells, such as red blood cells, white blood cells, and platelets. Changes in these levels may indicate how Tasigna is affecting the bone marrow and overall blood production.

A Peripheral Smear Examination may also be necessary to evaluate the morphology of blood cells for any abnormalities or changes. This test can provide detailed information on the size, shape, and number of blood cells, offering additional insights into how Tasigna is influencing blood cell development.

Regularly performing these related lab tests can help healthcare providers monitor the response to Tasigna treatment, assess any potential side effects, and make informed decisions to optimize patient care.


Additional Information

Habit FormingNo
Chemical ClassAminopyrimidines Derivative
Therapeutic Class-
Action ClassTyrosine kinase inhibitors

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The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Gowri Kulkarni

MBBS - General Medicine, DNB - Psychiatry, MRCGP [INT] Family Medicine, BSIC (BACP)

Last update on 11-Feb-2025