Premarin Vaginal Cream

By Premarin

Rx

14gm Vaginal Cream in a Tube

Composition icon

Composition

Conjugated Estrogens(0.625mg)

Manufacturer - Pfizer Ltd icon

Manufacturer - Pfizer Ltd

The Capital, 1802, 18th Floor , Plot No. C-70, 'G' Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.

Expires on or after icon

Expires on or after

May, 2026

About Premarin Vaginal Cream

PREMARIN VAGINAL is a Hormone Replacement Therapy medication containing Conjugated estrogens, a synthetic derivative of female sex hormones known as estrogen. It is primarily used to alleviate symptoms of estrogen deficiency, such as vaginal dryness, itching, inflammation, and thinning. Additionally, it can help with conditions like itching and inflammation of the vulva, labia minora, clitoris, and vaginal orifice, as well as moderate to severe genital pain during sexual intercourse resulting from menopause.

Conjugated estrogen works by supplementing the body with estrogen to maintain adequate levels during estrogen deficiency states. This action helps to prevent dryness, thinning, inflammation, and itching of the vaginal walls and genital area, thereby reducing genital pain. To ensure the safe use of PREMARIN VAGINAL, your doctor may recommend periodic blood tests and regular physical examinations, including breast examinations, to monitor for any potential side effects.

It is important not to use PREMARIN VAGINAL if you have a history of breast cancer, uterine cancer, unexplained vaginal bleeding, heart issues, or blood clots. Before starting treatment, it is crucial to inform your doctor about any liver or kidney problems, diabetes, migraine headaches, asthma, or epilepsy that you may have. This medication is not suitable for use in pregnant or breastfeeding women, as well as in children under 18 years of age.

Common side effects associated with the application of PREMARIN VAGINAL may include stomach pain, back pain, breast discomfort, headaches, vaginal infections, or vaginal discharge. If you experience any of these side effects and they worsen, it is advisable to consult your doctor promptly. Additionally, it is essential to watch out for any changes in your breasts, such as pain, tenderness, nipple discharge, or the development of lumps, as well as symptoms like heavy menstrual bleeding, leg pain, redness or swelling in the legs, sudden chest pain, or breathing difficulties after using PREMARIN VAGINAL.

Before initiating treatment with PREMARIN VAGINAL, it is important to follow your doctor's guidance and disclose any relevant medical history or conditions to ensure safe and effective use of this Hormone Replacement Therapy medication.


Benefits

Premarin Vaginal Cream is a medication commonly used in Hormone Replacement Therapy (HRT) to help alleviate symptoms experienced during menopause. Menopause can bring about uncomfortable symptoms like hot flushes, vaginal dryness, and a decrease in sex drive. By incorporating Estrogen, a crucial hormone alongside progesterone, this treatment aims to provide relief from these symptoms, leading to an enhancement in daily life and mood. The use of Estrogen in the form of vaginal cream allows for a straightforward and effective delivery of hormones. While other forms like tablets and gels are available, the cream offers a convenient and targeted approach for those experiencing vaginal dryness. It is imperative to follow the prescription provided by your healthcare provider and adhere to the recommended duration of treatment to fully benefit from the effects of Premarin Vaginal Cream in managing menopausal symptoms.


How to use the Premarin Vaginal Cream

To use Premarin Vaginal Cream, first, make sure you read the label and follow the directions provided. This medication is intended for external use only and should only be used as advised by your doctor. Begin by cleaning and drying the affected area. Next, using the applicator that comes with the cream, remove the cap from the tube and connect the nozzle end of the applicator with the tube.


Gently squeeze the appropriate amount of cream from the tube into the applicator, using the markings on the applicator as a guide to measure the correct dosage as per your doctor's instructions. Once the applicator is filled, lie down on your back or find a comfortable position that allows for easy application to the genital area. Carefully insert the applicator into the vagina and press the plunger down to release the cream.


After applying the cream, remove the applicator from the vagina. To clean the applicator, pull out the plunger and wash it thoroughly with mild soap and warm water. If you need to apply the cream to external parts of the vagina, such as the vulva, labia minora, clitoris, or vaginal orifice, take the required quantity of Premarin Vaginal Cream and apply it to the necessary sites on the genital area.


Remember, the correct dose and duration of therapy will be determined by your doctor based on factors like your age, body weight, and overall health condition. Always follow your physician's instructions carefully to ensure the safe and effective use of Premarin Vaginal Cream for your specific needs.


Uses of Premarin Vaginal Cream

Premarin Vaginal Cream is used for hormone replacement therapy to address several conditions. It is commonly used to treat atrophic vaginitis, which includes symptoms like vaginal itching, inflammation, dryness, and thinning of the vaginal walls. Additionally, the cream is effective in managing Kraurosis vulvae, a condition characterized by itching and inflammation of the vulva and other genital areas. For those experiencing moderate to severe dyspareunia, which refers to genital pain during sexual intercourse, Premarin Vaginal Cream can provide relief.


What conditions Premarin Vaginal Cream treats?

Premarin Vaginal Cream is a female sex hormone used in hormone replacement therapy to address symptoms of estrogen deficiency like hot flushes and vaginal dryness. It can also be used in treating certain cancers when combined with other anticancer medications. Dosage and treatment duration are determined by your doctor to properly manage symptoms. Common side effects include headaches, breast pain, and vaginal bleeding. It's crucial to seek medical help for serious symptoms like breast lumps or severe headaches. Before starting treatment, inform your doctor of any existing conditions or medications.


Should you consult a doctor?

Seek medical advice before using Premarin Vaginal Cream if you have unusual vaginal bleeding, a history of certain cancers or blood clots, a bleeding disorder, a previous stroke, or upcoming surgery. Inform your doctor if you have epilepsy, diabetes, migraines, are overweight, have high cholesterol, endometriosis, lupus, thyroid issues, or hypercalcemia. It is essential to consult a healthcare provider to ensure safe and appropriate use of Premarin Vaginal Cream given your specific medical history and conditions.


Side effects of Premarin Vaginal Cream

Premarin Vaginal Cream may cause certain side effects which usually do not require medical attention, as your body adapts to the medication. These side effects might include abnormal vaginal bleeding, irritation, pelvic pain, breast pain, irregular vaginal bleeding, swelling, vaginal spotting, vaginal itching, depression, leg cramps, abdominal cramps, and a burning sensation in the vagina. Other possible side effects could be headaches, stomach or abdominal cramps, bloating, nausea, vomiting, hair loss, fluid retention, vaginal yeast infections, and high blood sugar levels. If you experience any of these more severe side effects such as unexplained vaginal bleeding, signs of blood clots, liver problems, dementia, high blood pressure, migraine-like headaches, allergic reactions, breast cancer symptoms, or uterine cancer symptoms, it is essential to discontinue the use of Premarin Vaginal Cream immediately and contact your doctor for appropriate medical advice and intervention.


Safety advice

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liver

When it comes to using Premarin Vaginal Cream, there is no known interaction with the liver. This means that there is no specific safety advice or precautions related to liver issues when using this cream. It is important to follow the prescribed usage instructions and consult with your healthcare provider if you have any concerns regarding liver health. If you have any specific medical conditions related to the liver, it is recommended to seek guidance from your doctor before using Premarin Vaginal Cream.

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kidney

No interaction with kidneys has been found for Premarin Vaginal Cream. Consult with your doctor for proper guidance before using Premarin Vaginal Cream.

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alcohol

No interaction between alcohol and Premarin Vaginal Cream has been found. Caution should be taken during pregnancy.

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driving

It is safe to drive while using Premarin Vaginal Cream. No interactions affecting driving have been found or established.

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pregnancy

Premarin Vaginal Cream is considered unsafe during pregnancy due to the potential risks to the developing baby. It should only be used in life-threatening situations under a doctor's supervision if benefits outweigh risks. Consult your doctor before use.

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breastfeeding

Premarin Vaginal Cream may not be safe to use while breastfeeding. Limited data indicates it could pass into breastmilk and potentially harm the baby.


Age above 75(Geriatrics)

Premarin Vaginal CreamL should be used with caution in elderly women (aged 65 years or above). Therefore, consult your doctor before using it.


Age below 6 months(Pediatrics)

Premarin Vaginal Cream is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before using it.


Consumption warning before consuming Premarin Vaginal Cream

Before using Premarin Vaginal Cream, it is crucial to follow your doctor's guidance on dosage and timing. Skipping doses should be avoided, and the full course of treatment must be completed as prescribed. Abruptly stopping the treatment without consulting your doctor could reduce its effectiveness. Common side effects may include headaches, breast pain, and vaginal bleeding. Seek immediate medical help if you experience symptoms like breast lumps, unusual bleeding, or severe headaches. Inform your doctor about any other medications you are taking and disclose any history of blood clots or unexplained vaginal bleeding. If you are pregnant or breastfeeding, consult your doctor before using this hormone replacement therapy. Diagnostic tests may be recommended to monitor the effects of the medication on your body.


What if you forgot to take Premarin Vaginal Cream?

If you forget to use your dose of Premarin Vaginal Cream, take it when you remember. But if it's close to the time for your next dose, just skip the missed one. Don't use extra cream to make up for the dose you missed. It's important to stick to your regular schedule when using this medication.


What happens if you take overdose of Premarin Vaginal Cream?

If you or someone else has used too much Premarin Vaginal Cream by accident, it is important to seek help right away. Contact your doctor or go to the nearest hospital immediately. Signs of taking too much of the medication can include feeling nauseous, vomiting, having tender breasts, experiencing abdominal pain, feeling drowsy and tired, or having unexpected bleeding.


Additional Information

Habit FormingNo
Chemical ClassEstradiol Congeners
Therapeutic ClassGYNAECOLOGICAL
Action Class-

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Disclaimer

The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Mansi Chaudhari

MBBS - General Medicine

Last update on 01-Oct-2024