Pemgem 500mg Injection
By Pemgem
Rx
1 Injection in a Vial

Composition
Pemetrexed(500mg)

Manufacturer - Dr Reddy's Laboratories Ltd
Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA

Expires on or after
April, 2026
About Pemgem 500mg Injection
Pemgem 500mg Injection is a medication used to treat non-small cell lung cancer and malignant pleural mesothelioma. It contains Pemetrexed which is classified as an Anticancer agent. For patients with advanced stages of non-small cell lung cancer who have not responded well to conventional treatments, Pemgem 500mg Injection can be an option to help control the progression of the disease.
In the case of malignant pleural mesothelioma, which affects the protective membrane around the lungs, Pemgem 500mg Injection is often used in combination with other anti-cancer drugs like cisplatin or carboplatin to achieve more effective results. Before starting treatment with Pemgem 500mg Injection, it is vital to inform your doctor about any existing lung, liver, kidney, or heart conditions, as well as any history of such problems. Additionally, if you have fluid buildup in the lungs or are planning to undergo radiation therapy or vaccinations, it is important to discuss this with your healthcare provider.
This medication should only be administered by a qualified medical professional through injection. The dosage and frequency of administration will be determined by your doctor based on your specific condition and may be adjusted over time. It is crucial to strictly follow your doctor's instructions regarding the use of Pemgem 500mg Injection to avoid serious side effects. It may take some time before you notice the benefits of the treatment, so it is important not to discontinue the medication unless advised by your doctor.
Common side effects of Pemgem 500mg Injection include nausea, vomiting, loss of appetite, and hair loss. This medication may also decrease the number of blood cells in your body, making you more susceptible to infections. Regular monitoring through blood tests is necessary to check your blood cell levels, as well as the functioning of your heart, liver, and blood uric acid levels. Before starting Pemgem 500mg Injection, inform your doctor about any heart disease, liver or kidney problems, or if you are taking any other medications.
It is important to note that Pemgem 500mg Injection is not recommended for use during pregnancy or while breastfeeding. Both men and women receiving this treatment should use effective contraception to prevent pregnancy during therapy and up to six months after discontinuation. If you experience any worsening of side effects while on Pemgem 500mg Injection, it is essential to contact your doctor for guidance.
Benefits
Pemgem 500mg Injection offers powerful benefits in the treatment of both non-small cell lung cancer and malignant pleural mesothelioma. In cases of non-small cell lung cancer, which is a common type of lung cancer affecting both smokers and non-smokers, Pemgem 500mg Injection is effective either on its own or in conjunction with other medications. This medicine is potent and has shown to be toxic, so it is crucial to have a thorough discussion with your doctor about the potential risks and advantages before starting treatment. It's recommended to abstain from alcohol consumption while undergoing this treatment and to ensure proper hydration by drinking plenty of water.
On the other hand, in the case of malignant pleural mesothelioma, a particularly aggressive form of lung cancer, Pemgem 500mg Injection plays a key role in the treatment plan when combined with other drugs. By targeting and eliminating cancer cells, this medication works to halt the growth and spread of cancer within the lungs and surrounding areas. Following your doctor's instructions diligently and seeking clarification for any concerns that arise are essential steps to maximize the benefits of this treatment.
Overall, Pemgem 500mg Injection offers significant advantages in combating these challenging forms of cancer, highlighting its importance in the fight against non-small cell lung cancer and malignant pleural mesothelioma.
How to use the Pemgem 500mg Injection
When using Pemgem 500mg Injection, it is important to follow the guidance of your doctor or nurse. This medicine should only be administered by healthcare professionals and should not be self-administered. The injection will be given to you directly into a vein, known as an intravenous infusion. Your doctor will determine the right dosage and duration of treatment based on factors such as your age, body weight, and the specific condition being treated. It is crucial to adhere to the instructions provided by your healthcare provider to ensure the safe and effective use of Pemgem 500mg Injection.
Uses of Pemgem 500mg Injection
Pemgem 500mg Injection is used to treat advanced non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma, which is cancer affecting the protective layer of the lungs. This medication is specifically indicated for these conditions and can help in managing the symptoms and progression of the diseases. By targeting these specific types of cancer, Pemgem 500mg Injection plays a key role in the treatment plans for patients diagnosed with advanced NSCLC or malignant pleural mesothelioma.
What conditions Pemgem 500mg Injection treats?
Pemgem 500mg Injection is used to treat non-small cell lung cancer and malignant pleural mesothelioma. For non-small cell lung cancer, which affects both smokers and non-smokers, Pemgem may be given alone or with other medicines. It is crucial to discuss the benefits and risks with your doctor as it is a potent medicine. Avoid alcohol and stay hydrated during treatment. Malignant pleural mesothelioma is an aggressive lung cancer type. Pemgem is used with other medicines to kill cancer cells and prevent further growth. Follow your doctor’s instructions closely and seek clarification if needed.
Should you consult a doctor?
Seek medical attention immediately if you experience any of the following after receiving Pemgem 500mg Injection: severe allergic reactions like difficulty breathing, swelling of the face or throat; signs of infection such as fever, chills, or persistent sore throat; unusual bleeding or bruising; dark urine or persistent nausea/vomiting; severe stomach/abdominal pain; yellowing of the eyes or skin. It is important to consult your healthcare provider if you have a history of radiation therapy or have been recently vaccinated before starting this medication. Always inform your doctor about your medical history and any recent treatments to ensure the safe use of Pemgem 500mg Injection.
Side effects of Pemgem 500mg Injection
Pemgem 500mg Injection may cause various side effects, although most of them tend to resolve as your body gets used to the medication. Common side effects include nausea, vomiting, sore throat, loss of appetite, and stomatitis (mouth inflammation). Other possible side effects are hair loss, low blood platelets, rash, fatigue, anemia, diarrhea, decreased white blood cell count, and neuropathy. Additionally, patients may experience rectal inflammation or bleeding, esophagus redness and inflammation, infections, fever, and sore throat. Hair loss, stomach issues like pain or diarrhea, mouth ulcers, tiredness, skin rash, and sensory changes on the skin are also reported. Some individuals may notice muscle weakness, eye problems, irregular heartbeat, increased liver and kidney enzymes, body swelling, and gut inflammation.
It is important to contact your healthcare provider immediately if you experience certain severe side effects after using Pemgem 500mg Injection. These include fever, increased infections, chest pain, fast heart rate, mouth inflammation with pain and swelling, signs of allergic reactions, severe skin reactions, symptoms of low red blood cells (such as tiredness and pale skin), increased bleeding tendency, unexpected bruising, and signs of blood clot in the lungs like breathlessness and chest pain. If any of these symptoms occur, seeking medical attention promptly is recommended.
Safety advice

liver
Pemgem 500mg Injection is considered safe for individuals with liver disease based on the available data. It is noted that there may not be a requirement to adjust the dosage of Pemgem 500mg Injection for patients with liver issues. It is advised to seek guidance from your healthcare provider before using this medication if you have liver concerns.

kidney
Pemgem 500mg Injection should be used carefully if you have kidney problems. Your doctor may adjust the dose based on your condition. Avoid using it if you have moderate to severe kidney disease. Always consult your doctor.

alcohol
When consuming alcohol with Pemgem 500mg Injection, no harmful side effects are expected. It is important to be cautious during pregnancy.

driving
**Caution - Driving** Pemgem 500mg Injection might cause tiredness, affecting driving ability.

pregnancy
Pemgem 500mg Injection is not safe to use during pregnancy due to the risk it poses to the developing baby. Only in life-threatening situations with significant benefits, a doctor may prescribe it. Consult your doctor for guidance.

breastfeeding
During breastfeeding, use Pemgem 500mg Injection with caution. It is advisable to pause breastfeeding until the mother completes the treatment and the medication is fully eliminated from her system.
Age above 75(Geriatrics)
Age below 6 months(Pediatrics)
Consumption warning before consuming Pemgem 500mg Injection
Before taking Pemgem 500mg Injection, it is important to follow your doctor's instructions carefully. This medication is administered as an injection by a qualified healthcare professional. Your doctor will determine the appropriate dosage and frequency based on your condition, which may change over time. Taking the medication incorrectly or in excessive amounts can lead to serious side effects. It may take some time before you notice any benefits, so do not discontinue treatment without consulting your doctor.
Common side effects of Pemgem 500mg Injection include nausea, vomiting, loss of appetite, and hair loss. It can also reduce the number of blood cells, making you more susceptible to infections. Regular blood tests are necessary to monitor blood cell levels, as well as heart, liver, and blood uric acid levels.
Inform your doctor if you have heart disease, liver or kidney issues, or are taking medications for infections. This medicine may interact with other medications, so disclose all your current medications. Avoid using this medicine during pregnancy or breastfeeding, and use effective contraception methods to prevent pregnancy during treatment.
What happens if you take overdose of Pemgem 500mg Injection?
Pemgem 500mg Injection is a medication that should only be given to you by a doctor or nurse in a hospital setting. This helps to reduce the chance of receiving too much of the medication, which is called an overdose. However, if you notice any unusual symptoms after receiving the injection, it is important to talk to your doctor or nurse right away. Being aware of any potential signs of an overdose and seeking help promptly is crucial for your safety and well-being. Remember that your healthcare provider is there to assist you and answer any questions or concerns you may have regarding your treatment.
Additional Information
Habit Forming | No |
Chemical Class | Glutamic Acid Derivatives |
Therapeutic Class | ANTI NEOPLASTICS |
Action Class | Antimetabolites |
FAQs
Disclaimer
The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.
₹5635.75
Inclusive of all taxes
Content verified by

Dr. Archana Prabhakar
MBBS, M.Med (Family Medicine)
Last update on 11-Feb-2025