Kombiglyze XR 5mg/1000mg Tablet

By Kombiglyze

Rx

7 Tablet ER in a Strip

Composition icon

Composition

Saxagliptin(5mg) + Metformin(1000mg)

Manufacturer - AstraZeneca icon

Manufacturer - AstraZeneca

Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore

Expires on or after icon

Expires on or after

September, 2026

About Kombiglyze XR 5mg/1000mg Tablet

Kombiglyze XR 5mg/1000mg Tablet is a combination medication used to manage high blood sugar levels in individuals with type 2 diabetes mellitus. It helps in preventing severe complications associated with diabetes such as kidney damage, blindness, heart attacks, and strokes. This tablet can be prescribed alone or alongside other diabetes medications, with the best results seen when combined with a healthy diet and regular exercise routine.

The dosage of Kombiglyze XR 5mg/1000mg Tablet is determined based on individual conditions, blood sugar levels, and concurrent medications. It is recommended to take this medication consistently at the same time every day to optimize its benefits. The tablet is most effective when taken with meals to lower the risk of stomach upset. By regulating blood sugar levels, Kombiglyze XR 5mg/1000mg Tablet plays a vital role in preventing future diabetes-related complications.

Some common side effects of this medication may include diarrhea, nausea, vomiting, upset stomach, headache, and sore throat. There is a potential risk of low blood sugar levels (hypoglycemia) when used in conjunction with other diabetes medications like insulin or sulfonylureas. Patients should be informed on how to identify and manage hypoglycemia symptoms.

Before starting Kombiglyze XR 5mg/1000mg Tablet, individuals should inform their healthcare provider about any history of kidney, liver, or heart disease, pancreatic issues, excessive alcohol consumption, or if they are pregnant or breastfeeding. It is crucial to disclose all other medications being taken to avoid possible interactions. Patients are advised to avoid alcohol consumption as it can lower blood glucose levels.

Kombiglyze XR 5mg/1000mg Tablet consists of two active ingredients, Saxagliptin and Metformin, which work together to regulate blood glucose levels effectively. Saxagliptin blocks the enzyme DPP-4, promoting insulin production only when necessary and reducing excess blood sugar from the liver. Metformin, on the other hand, lowers liver glucose production, delays glucose absorption, and enhances insulin sensitivity.

Regular monitoring of blood sugar levels and kidney function may be necessary during Kombiglyze XR 5mg/1000mg Tablet treatment. Patients should adhere to their doctor's recommendations and not discontinue the medication abruptly despite improvements in their condition, as this could lead to a surge in blood sugar levels. This medication is not recommended for patients with severe kidney or liver disease and should be closely monitored when taken with digoxin.


Benefits

Kombiglyze XR 5mg/1000mg Tablet offers numerous benefits in the treatment of Type 2 diabetes mellitus. This medication combines Saxagliptin and Metformin, working together to lower blood glucose levels effectively. By managing blood glucose levels, Kombiglyze XR reduces the risk of serious complications associated with diabetes, including kidney damage, eye damage, nerve problems, and even limb loss. Maintaining proper control over diabetes with the help of this medication can also lower the risk of heart disease and stroke.

When used consistently in conjunction with a healthy diet and regular exercise, Kombiglyze XR supports patients in living a normal and healthy life. It is crucial to adhere to the prescribed regimen of Kombiglyze XR because it plays a significant role in protecting and securing your future health. This medication is particularly beneficial in preventing complications such as eyesight loss (retinopathy), kidney issues (nephropathy), nerve damage (neuropathy), diabetic foot ulcers, and delayed wound healing.

Overall, Kombiglyze XR 5mg/1000mg Tablet offers a comprehensive approach to managing Type 2 diabetes mellitus by effectively controlling blood sugar levels and reducing the risks associated with the disease. Consistent use of this medication, alongside lifestyle modifications, can significantly improve the quality of life for individuals living with diabetes.


How to use the Kombiglyze XR 5mg/1000mg Tablet

To use Kombiglyze XR 5mg/1000mg Tablet, follow your doctor's instructions on the dose and duration. Swallow the tablet whole with a glass of water. Avoid chewing, crushing, or breaking it before swallowing. It is important to take Kombiglyze XR 5mg/1000mg Tablet with food. You can take it with or after meals as recommended by your physician. It is advised not to change the dose or stop taking the medication without consulting your doctor. Your doctor will determine the right dosage and duration based on factors such as your age, weight, and medical condition. Always follow your doctor's guidance for the best results.


Uses of Kombiglyze XR 5mg/1000mg Tablet

Kombiglyze XR 5mg/1000mg Tablet is primarily used for the treatment of Type 2 diabetes mellitus, a condition also known as non-insulin-dependent diabetes. This medication is effective in managing Type II diabetes mellitus by helping to regulate blood sugar levels. It is prescribed to individuals with Type 2 diabetes to assist in the control of their condition.


What conditions Kombiglyze XR 5mg/1000mg Tablet treats?

Type 2 diabetes is a condition where the body struggles to produce enough insulin or effectively use the insulin it makes, leading to high blood sugar levels. Symptoms may include increased thirst, frequent urination, hunger, fatigue, and blurred vision. Complications of type 2 diabetes can involve nerve problems, kidney issues, eye damage or blindness, limb loss, sexual dysfunction, and heightened risk of heart attack or stroke.


Should you consult a doctor?

Seek medical attention if you experience severe, uncontrollable diabetes, diabetic coma or precoma, nausea, vomiting, diarrhea, rapid weight loss, lactic acidosis or ketoacidosis, dehydration, severe systemic infections, shock, blood circulation problems, or alcoholism while taking KOMBIGLYZE XR 5/1000MG TABLET. Inform your doctor if you have type I diabetes, plan to undergo surgery, or have a history of pancreatic diseases before starting this medication. It is important to consult a healthcare provider for appropriate evaluation and guidance based on individual health conditions.


Side effects of Kombiglyze XR 5mg/1000mg Tablet

Side Effects:

When taking Kombiglyze XR 5mg/1000mg Tablet, you may experience some side effects as your body adjusts to the medication. These side effects tend to be mild and typically do not require medical attention. Common side effects include nausea, vomiting, diarrhea, and decreased appetite. Hypoglycemia, which is low blood sugar, can also occur. Additionally, you may experience urinary tract infections and inflammation of the throat and nasal passages known as nasopharyngitis.

Some other potential side effects of Kombiglyze XR may include dizziness, sweating, palpitations, dry mouth, dry skin, and further instances of hypoglycemia. Joint pain, erectile dysfunction, headache, muscle pain, and taste changes like a metallic taste have also been reported. Digestive issues such as stomach pain, indigestion, bloating, and stomach infections may occur. Respiratory problems like sinus infections, sore throat, cold symptoms, and nasal inflammation are also possible adverse reactions.

It is essential to consult your doctor if you experience any persistent side effects or if you have concerns about the impact of Kombiglyze XR on your health.


Safety advice

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liver

Kombiglyze XR 5mg/1000mg Tablet may not be safe for individuals with liver disease, and it is recommended to avoid using this medication in such cases. It is crucial to consult with your doctor regarding the suitability of Kombiglyze XR in relation to liver health before taking this medication.

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kidney

Kombiglyze XR 5mg/1000mg Tablet may not be safe for individuals with kidney disease. It is best to avoid using it if you have kidney issues. Please consult your doctor for guidance.

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alcohol

It is not safe to drink alcohol while taking Kombiglyze XR 5mg/1000mg Tablet.

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driving

When experiencing low or high blood sugar symptoms, refrain from driving to ensure safety.

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pregnancy

Kombiglyze XR 5mg/1000mg Tablet is considered unsafe during pregnancy. Animal studies indicate potential harm to the developing baby. Your doctor will evaluate the benefits versus risks before recommending its use. Please consult your doctor.

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breastfeeding

Kombiglyze XR 5mg/1000mg Tablet is probably unsafe during breastfeeding. Limited data indicates it may pass into breastmilk and harm the baby.


Age above 75(Geriatrics)

KOMBIGLYZE XR 5/1000MG TABLET should be used with caution among the elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

Age below 6 months(Pediatrics)

KOMBIGLYZE XR 5/1000MG TABLET is not generally recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

Consumption warning before consuming Kombiglyze XR 5mg/1000mg Tablet

Before consuming Kombiglyze XR 5mg/1000mg Tablet 7's, be aware of potential risks. Prolonged use may lead to acute pancreatitis and kidney issues. If combined with other anti-diabetic medications or insulin, there is an increased chance of hypoglycemia. Your doctor may need to adjust the dosage accordingly. Additionally, severe allergic reactions such as anaphylaxis, angioedema, and skin conditions like Stevens-Johnson syndrome may occur in some individuals. It is crucial to be vigilant about these possibilities and consult your healthcare provider if you experience any concerning symptoms while taking Kombiglyze XR 5mg/1000mg Tablet 7's.


What if you forgot to take Kombiglyze XR 5mg/1000mg Tablet?

If you forget to take a dose of Kombiglyze XR 5mg/1000mg Tablet, try to take it as soon as you remember. But if it's close to your next scheduled dose, just skip the missed one and continue with your normal dosing routine. Avoid taking a double dose to make up for the missed one. It's important to stay consistent with your medication schedule to ensure its effectiveness in managing your condition.


What happens if you take overdose of Kombiglyze XR 5mg/1000mg Tablet?

If an individual takes more Kombiglyze XR 5mg/1000mg Tablet than prescribed, it is considered an overdose. It is important to seek immediate medical attention by consulting a doctor or visiting the nearest hospital. Overdosing on this medication can lead to serious health complications and should not be taken lightly. It is crucial to follow the prescribed dosage instructions carefully to avoid the risks associated with an overdose.


Related lab tests

For individuals taking Kombiglyze XR 5mg/1000mg Tablet, there are specific lab tests that may be relevant to monitor their health and treatment progress. Fasting Blood Glucose test is important to check the level of glucose in the blood after an overnight fast. This test helps to assess how well the body is managing blood sugar levels before eating. Postprandial Blood Glucose test, on the other hand, measures the blood sugar level a few hours after eating. This test can help evaluate how the body processes glucose after a meal. Another significant lab test is the Glycosylated Hemoglobin test, which indicates the average blood sugar levels over the past 2-3 months. Monitoring this test provides insights into long-term blood sugar control. These lab tests are essential in guiding the management of diabetes and ensuring the effectiveness of Kombiglyze XR 5mg/1000mg Tablet therapy.

Related Lab Tests:
1. Glucose - Fasting Blood
2. Glucose - Postprandial Blood
3. Glycosylated Hemoglobin


Additional Information

Habit FormingNo
Chemical Class-
Therapeutic ClassANTI DIABETIC
Action Class-

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The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Monie Riju Simon

MBBS - General Medicine

Last update on 11-Feb-2025