Jakavi 5mg Tablet

By Jakavi

Rx

14 Tablet in a Strip

Composition icon

Composition

Ruxolitinib(5mg)

Manufacturer - Novartis India Ltd icon

Manufacturer - Novartis India Ltd

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India

Expires on or after icon

Expires on or after

April, 2026

About Jakavi 5mg Tablet

Jakavi 5mg Tablet is a medication prescribed for the treatment of chronic idiopathic myelofibrosis and Polycythemia vera. It belongs to a group of medicines known as kinase inhibitors. The active ingredient in Jakavi 5mg Tablet is Ruxolitinib, which works by blocking the signals responsible for cancer cell multiplication in conditions like myelofibrosis and polycythemia vera.

When taking Jakavi 5mg Tablet, it is advised to follow your doctor's instructions on dosage and timing. It can be taken with or without food, but it is recommended to take it at the same time every day for maximum benefits. The dosage and frequency will be determined by your doctor based on your condition and may be adjusted over time. It is crucial to take the medication exactly as prescribed to avoid serious side effects.

Common side effects of Jakavi 5mg Tablet include headache, dizziness, and low platelet count. This medication may also reduce blood cell counts, making the body more susceptible to infections. Regular blood tests are necessary to monitor blood cell levels, as well as heart, liver, kidney, and lipid levels. Prior to starting Jakavi 5mg Tablet, inform your doctor about any existing liver or kidney issues, as well as any other medications you may be taking to prevent potential interactions.

It is important to note that Jakavi 5mg Tablet is not recommended during pregnancy or while breastfeeding. Effective contraception is advised for both males and females while undergoing treatment to prevent pregnancy. If you experience any persistent side effects or have concerns about the medication, consult your healthcare provider for guidance.


Benefits

Jakavi 5mg Tablet is a medication that offers several benefits for individuals suffering from conditions like polycythemia vera and chronic idiopathic myelofibrosis. In cases of polycythemia vera, which is a form of blood cancer characterized by the excess production of red blood cells leading to potential complications like blood clot formation, Jakavi 5mg Tablet works by either killing or inhibiting the growth of cancer cells. By doing so, it helps prevent the further multiplication of cancer cells in the body.

Similarly, for individuals with chronic idiopathic myelofibrosis, a condition where scar tissue forms in the bone marrow, disrupting normal blood cell production, Jakavi 5mg Tablet offers relief by targeting and stopping the growth of cancer cells. However, it is important to note that while this medication is effective, it can also have some side effects. It is essential to communicate any concerns or uncertainties regarding these side effects with your healthcare provider.

Furthermore, Jakavi 5mg Tablet contains Ruxolitinib, a kinase inhibitor that specifically blocks enzymes known as Janus Associated Kinases (JAK1 and JAK2). By doing so, it can reduce the size of the spleen in patients with myelofibrosis, alleviate symptoms such as bone pain, fever, night sweats, and weight loss, and decrease the production of red blood cells in individuals with polycythemia vera. These actions can potentially lower the risk of serious blood clotting or vascular issues in patients.

In addition to treating myelofibrosis and polycythemia vera, Jakavi 5mg Tablet is also indicated for the management of graft-versus-host disease in both adults and children over 12 years old. By reducing the signs and symptoms of acute and chronic forms of graft-versus-host disease, Jakavi 5mg Tablet aids in improving the condition and ensuring the survival of transplanted cells.

It is important to note that while undergoing treatment with Jakavi 5mg Tablet, it is advisable to abstain from alcohol and smoking, as well as to maintain proper hydration by drinking plenty of water. As with any medication, it is crucial to have a thorough discussion with your doctor about the potential risks and benefits associated with Jakavi 5mg Tablet before starting the treatment.


How to use the Jakavi 5mg Tablet

To use Jakavi 5mg Tablet, follow your doctor's instructions carefully. Take the tablet whole with a full glass of water; do not crush, chew, or break it. You can take Jakavi 5mg Tablet with or without food, but try to take it at the same time every day for best results. It's essential to take the medication exactly as prescribed to ensure it works effectively. If you have any questions about how to use Jakavi 5mg Tablet, consult your doctor for guidance.


Uses of Jakavi 5mg Tablet

Jakavi 5mg Tablet is primarily used for the treatment of polycythemia vera and chronic idiopathic myelofibrosis. It is also prescribed for myelofibrosis, polycythemia vera (PV), and graft-versus-host disease (GVHD).


What conditions Jakavi 5mg Tablet treats?

Jakavi 5mg Tablet is used to treat myelofibrosis, a bone marrow disorder where scar tissue replaces normal marrow, leading to insufficient blood cell production. Enlargement of the spleen is a typical sign. Symptoms include abdominal fullness, bone pain, fatigue, easy bleeding/bruising, pale skin, and weight loss. This medication is also prescribed for polycythaemia vera, another bone marrow disorder causing an excess of red blood cells. Symptoms of PV include headache, confusion, dizziness, itching, night sweats, and extreme tiredness. In addition, Jakavi 5mg Tablet may be used to manage graft-versus-host disease, which arises after a transplant when the donor cells attack the recipient's organs. Symptoms can include abdominal pain, mouth ulcers, and rash.


Should you consult a doctor?

If you experience persistent side effects like headache, dizziness, or a low platelet count while taking Jakavi 5mg Tablet, it’s essential to consult your doctor. Additionally, if you notice symptoms of anemia such as fatigue or weakness, seek medical attention promptly. Regular blood tests are necessary to monitor your blood cell levels as this medicine may decrease red blood cells, making you more prone to infections. Inform your doctor if you have liver or kidney issues, or if you are taking other medications. It's crucial to follow your doctor's prescribed dosage and not stop taking the medication without their guidance. Notifying your healthcare team about all the medications you are using is important, as interactions can occur. Avoid taking Jakavi 5mg Tablet during pregnancy or while breastfeeding, and practice effective contraception during treatment to prevent pregnancy.


Side effects of Jakavi 5mg Tablet

When taking Jakavi 5mg Tablet, some common side effects may occur. These side effects may not need medical attention and often go away as your body gets used to the medicine. However, it is important to consult your doctor if these side effects persist or if you are concerned about them. Possible side effects include headaches, dizziness, low blood platelets, and anemia (a low number of red blood cells).

Dizziness and headaches are commonly reported side effects of Jakavi 5mg Tablet. Additionally, some individuals may experience weight gain, fever, cough, urinary tract infections, constipation, and hypertriglyceridemia (high cholesterol levels). It is important to be aware of these potential side effects and consult with your healthcare provider if you experience any of them.


Safety advice

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liver

When using Jakavi 5mg Tablet, it is important to be cautious if you have liver disease. It may be necessary to adjust the dose of Jakavi 5mg Tablet in such cases. Consulting your doctor is advised to ensure the proper use of the medication.

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kidney

Jakavi 5mg Tablet requires caution in patients with kidney disease. Dose adjustment may be necessary, and it is not recommended for use in patients with moderate to severe kidney disease. Consulting the doctor is important.

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alcohol

It is safe to drink alcohol while taking Jakavi 5mg Tablet as it does not have any harmful effects.

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driving

Jakavi 5mg Tablet may cause decreased alertness, impact vision, and induce drowsiness or dizziness. Avoid driving if experiencing these effects.

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pregnancy

Jakavi 5mg Tablet may not be safe to use during pregnancy, as animal studies have shown harmful effects on the developing baby. Your doctor will consider the benefits and risks before prescribing it to you. Please consult your doctor regarding its use during pregnancy.

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breastfeeding

Jakavi 5mg Tablet may be unsafe during breastfeeding as it may pass into breastmilk and harm the baby.


Consumption warning before consuming Jakavi 5mg Tablet

Before taking Jakavi 5mg Tablet 10's, do not use it if you have allergies to any of its ingredients, or if you are pregnant or breastfeeding. It is essential to inform your doctor about any past or current infections, such as tuberculosis, hepatitis B, or HIV. Additionally, disclose any history of kidney or liver issues, skin cancer, anaemia, blood clots, heart problems, shingles, high cholesterol, or smoking habits. Seek immediate medical help if you notice symptoms of a blood disorder, infections, tuberculosis, serious brain infection, shingles, or skin cancer. Symptoms can range from unexpected bleeding, coughing with blood-tinged sputum, to confusion or difficulty thinking. Also, inform your healthcare provider about any other medications, supplements, or herbal products you may be using.


Disease interactions

When taking Jakavi 5mg Tablet, it is crucial to inform your doctor about any pre-existing medical conditions you may have. This includes heart problems, thrombosis (blood clots), hepatitis B infection, tuberculosis, infections, high lipid levels, lung problems, low blood count, or cancer. Providing this information is essential for your doctor to assess the potential interactions between these conditions and the medication, ensuring your safety and optimal treatment outcomes.


Additional Information

Habit FormingNo
Chemical ClassPyrrolo[2,3-d]pyrimidines Derivative
Therapeutic Class-
Action ClassTyrosine kinase inhibitors

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Disclaimer

The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Monie Riju Simon

MBBS - General Medicine

Last update on 11-Feb-2025