Imbruvica 140mg Capsule

By Imbruvica

Rx

120 Capsule in a Bottle

Composition icon

Composition

Ibrutinib(140mg)

Manufacturer - Janssen Pharmaceuticals icon

Manufacturer - Janssen Pharmaceuticals

Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060

Expires on or after icon

Expires on or after

July, 2025

About Imbruvica 140mg Capsule

Imbruvica 140mg Capsule is a medication used to treat mantle-cell lymphoma, chronic lymphocytic leukemia (CLL), and other types of blood cancer in adults. This medicine contains Ibrutinib, a type of protein kinase inhibitor that works by blocking the action of Bruton's tyrosine kinase, a protein that plays a role in the growth and survival of cancer cells. By inhibiting this protein, Imbruvica helps in killing cancer cells and slowing down the progression of the disease.

The dosage of Imbruvica 140mg Capsule should be taken as prescribed by the doctor, and the duration of treatment will depend on how well the patient responds to the medication. Regular blood tests may be conducted by the doctor to monitor the levels of blood cells during the treatment. It is important to note that Imbruvica may lead to a decrease in blood cell counts, which can increase the risk of infections. Common side effects of this medicine may include headache, diarrhea, and nausea. If any of these side effects persist or worsen, it is advisable to consult the doctor promptly.

Patients should not take Imbruvica 140mg Capsule if they are pregnant or breastfeeding, as it may cause harm to the unborn baby or nursing infant. It is vital to inform the doctor about any existing health conditions or medications being taken to avoid potential interactions or adverse effects. This medication is recommended for use in adults only, as its safety and effectiveness have not been established in children.

In summary, Imbruvica 140mg Capsule is a targeted therapy that effectively treats certain types of blood cancers by blocking specific proteins involved in cancer cell growth. Patients should adhere to the prescribed dosage, report any side effects to the doctor, and follow professional medical advice throughout the treatment duration.


Benefits

Imbruvica 140mg Capsule is a medication belonging to a group of anti-cancer drugs known as protein kinase inhibitors. It is used to treat various types of blood cancers in adults, including mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström's macroglobulinemia. Additionally, this medication can also be beneficial in the treatment of marginal zone lymphoma and chronic graft vs host disease.

The key ingredient in Imbruvica 140mg Capsule is Ibrutinib, which targets Bruton's tyrosine kinase, a protein essential for the growth and survival of cancer cells. By blocking this protein, Imbruvica helps in killing and reducing the number of cancer cells in the body. This action not only combats the existing cancer cells but also slows down the progression of the disease, ultimately improving the patient's condition and quality of life.

Imbruvica's mechanism of action makes it an effective treatment option for the mentioned blood cancers, offering patients a chance to manage their condition and possibly achieve better outcomes. It is important to follow the prescribed dosage and instructions while using Imbruvica to fully benefit from its anti-cancer properties and minimize potential side effects.


How to use the Imbruvica 140mg Capsule

To use Imbruvica 140mg Capsule, follow your doctor's instructions on dosage and duration. You can take this capsule with or without food, but it's recommended to take it at the same time every day. Swallow the capsule whole with water; do not crush or chew it. This medication is most effective when taken consistently as prescribed by your doctor. If you have any questions about how to use Imbruvica 140mg Capsule, consult your healthcare provider for further guidance.


Uses of Imbruvica 140mg Capsule

Imbruvica 140mg Capsule is used to treat three different types of blood cancers: mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenström's macroglobulinaemia. These cancers affect the white blood cells and lymphatic system. Imbruvica works by targeting specific proteins in the cancer cells, preventing them from growing and spreading. It is prescribed by doctors to patients who have not responded well to other treatments or have relapsed. Imbruvica helps to control the growth of cancer cells, improve symptoms, and increase overall survival in patients with these types of blood cancers.


What conditions Imbruvica 140mg Capsule treats?

Imbruvica 140mg Capsule is used to treat Mantle Cell Lymphoma, Chronic Lymphocytic Leukaemia, and Waldenström's Macroglobulinaemia. These are different types of cancers that affect the lymph nodes and blood cells. Common symptoms include swollen lymph nodes, fatigue, easy bruising, and pain. Treatment with Imbruvica helps to target the cancer cells and manage these symptoms effectively.


Should you consult a doctor?

When taking Imbruvica 140mg Capsule, it is important to seek your doctor's advice if you experience persistent or worsening side effects such as headache, diarrhea, or nausea. Additionally, it is crucial to consult your doctor if you notice any of the following symptoms: fever, stomatitis (inflammation of the mouth), low blood platelets, decreased white blood cell count, fatigue, musculoskeletal pain, rash, anemia, bruising, muscle spasm, hemorrhage, pneumonia, cough, dry eye, high blood pressure, weight loss, urinary tract infection, peripheral edema, subdural hematoma, or second primary malignancies. Your doctor may need to monitor your blood cell levels regularly to ensure the medication is not causing any adverse effects. Remember, most side effects tend to resolve on their own, but it is important to seek medical attention if you have concerns about any symptoms you are experiencing.


Side effects of Imbruvica 140mg Capsule

Imbruvica 140mg Capsule may cause side effects. These side effects are usually mild and may go away on their own as your body gets used to the medication. However, if the side effects persist or are concerning to you, it is important to consult your doctor for guidance. Common side effects of Imbruvica 140mg Capsule may include headache, fever, diarrhea, stomatitis (inflammation of the mouth), nausea, low blood platelets, decreased white blood cell count (neutrophils), fatigue, musculoskeletal pain, rash, anemia, bruising, muscle spasm, hemorrhage, pneumonia, cough, dry eye, high blood pressure, weight loss, urinary tract infection, peripheral edema, subdural hematoma, and second primary malignancies.

Some individuals may also experience nausea, vomiting, diarrhea, constipation, fatigue, dizziness, and mouth sores while taking Imbruvica 140mg Capsule. It is important to be aware of these potential side effects and discuss any concerns with your healthcare provider.


Safety advice

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liver

When it comes to your liver health, it's important to use Imbruvica 140mg Capsule with caution. If you have any liver disease, make sure to consult your doctor before taking this medication, as dose adjustment may be necessary. Additionally, if you have a history of liver issues, it's essential to inform your doctor before starting Imbruvica treatment. For patients with moderate or severe liver impairment, it is advisable to avoid using Imbruvica 140mg Capsule unless otherwise directed by a healthcare professional. In cases of mild liver impairment, dose adjustments may be needed for safe use. Always prioritize your liver health when considering Imbruvica 140mg Capsule treatment.

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kidney

Imbruvica 140mg Capsule should be used cautiously if you have kidney disease. Your doctor may need to adjust the dose. Inform your doctor if you have a history of kidney issues before taking this medication.

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alcohol

Consult your doctor when consuming alcohol with Imbruvica 140mg Capsule. Avoid alcohol while using this medication, as its effects are not fully understood and could potentially worsen your condition.

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driving

Imbruvica 140mg Capsule may lead to dizziness and tiredness, affecting driving ability. Avoid driving or using machinery if experiencing such side effects.

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pregnancy

Imbruvica 140mg Capsule should not be used during pregnancy due to potential harm to the baby. It falls under pregnancy category D. Consult your doctor for guidance. Practice effective contraception during Imbruvica 140mg Capsule treatment to avoid pregnancy risks.

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breastfeeding

Imbruvica 140mg Capsule should be used with caution during breastfeeding. It is advised to hold breastfeeding until the mother's treatment is completed and the drug is eliminated from her body. Avoid breastfeeding while taking Imbruvica 140mg Capsule.


Consumption warning before consuming Imbruvica 140mg Capsule

Before taking Imbruvica 140mg Capsule, it is important to note certain precautions to ensure your safety and well-being. Do not use this medication if you have allergies to any of its ingredients, if you are currently using St. John's wort, or if you are pregnant or breastfeeding. Inform your healthcare provider about any history of unusual bruising or bleeding, irregular heartbeat, heart issues, hepatitis B infection, liver conditions, high blood pressure, kidney disorders, or scheduled surgeries. Seek immediate medical help if you experience symptoms like progressive multifocal leukoencephalopathy (brain infection), stroke, heart failure, spleen rupture, infections, or haemophagocytic lymphohistiocytosis (inflammatory disorder). These symptoms include various indicators such as memory loss, sudden confusion, shortness of breath, abdominal pain, fever, weakness, or skin rash. It is crucial to be aware of these warnings before consuming Imbruvica 140mg Capsule to prevent any potential complications.


Disease interactions

When taking Imbruvica 140mg Capsule, it is essential to inform your doctor if you have certain medical conditions such as an irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, or kidney problems. These conditions may interact with Imbruvica and affect its effectiveness or pose a risk to your health. By disclosing your medical history to your healthcare provider, they can ensure the safe and appropriate use of Imbruvica while managing any potential interactions with your existing health conditions.


Related lab tests

When taking Imbruvica 140mg Capsule, it is important to monitor certain lab tests to ensure the medication is working effectively and not causing any adverse effects. One crucial test is the Complete Blood Count, which helps assess various components of your blood, such as red blood cells, white blood cells, and platelets. This test can detect potential issues like anemia or infections that may require adjustments to your treatment plan.

Another related lab test is the Cyclin D1 test, which evaluates the levels of a protein that plays a role in cell growth and division. This test can be helpful in monitoring the progression of certain types of cancers, as Imbruvica is commonly used in the treatment of hematological malignancies. By tracking Cyclin D1 levels, healthcare providers can gauge the response to treatment and make informed decisions about ongoing therapy.

Additionally, a Peripheral Smear Examination may be recommended while on Imbruvica to examine the appearance of red blood cells, white blood cells, and platelets under a microscope. This test can provide valuable information about blood cell morphology and help identify abnormalities that may indicate underlying health issues.

In summary, the related lab tests for individuals taking Imbruvica 140mg Capsule include Complete Blood Count, Cyclin D1 test, and Peripheral Smear Examination. These tests are essential for monitoring treatment progress, detecting any potential complications, and ensuring the best possible outcomes for patients.


Additional Information

Habit FormingNo
Chemical ClassDiphenyl Ether Derivative
Therapeutic Class-
Action ClassBruton's tyrosine kinase (BTK) inhibitors

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The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Upasana Bhatia

MBBS - General Medicine

Last update on 11-Feb-2025