Denub 60mg Injection

By Denub

Rx

1ml Injection in a Prefilled syringe

Composition icon

Composition

Denosumab(60mg)

Manufacturer - Alkem Laboratories Ltd icon

Manufacturer - Alkem Laboratories Ltd

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.

Expires on or after icon

Expires on or after

April, 2026

Benefits

Denub 60mg Injection, specifically Denub 60mg Injection, offers several benefits for those suffering from osteoporosis and other related conditions. This medication is particularly useful for postmenopausal women and men who are at higher risk of fractures. By belonging to a group of medicines called RANK ligand inhibitors, Denub 60mg Injection helps slow down the rate at which bones break down in the body. This results in maintaining bone density and ultimately reduces the risk of fractures.


In addition to treating osteoporosis, Denub 60mg Injection is also effective in addressing bone loss due to various factors, such as hormone level reductions from surgery or certain medications, long-term glucocorticoid treatment, and conditions like multiple myeloma and giant cell tumors of the bone. By binding to a protein on RANK ligand on osteoclasts, which are cells responsible for bone breakdown, this injection inhibits their formation, functioning, and survival. Consequently, bone breakdown is reduced, bone density is increased, and overall bone strength is improved.


Furthermore, Denub 60mg Injection plays a crucial role in treating giant cell tumor of bone (GCTB) by blocking specific receptors in the tumor cells, thus slowing down tumor growth. It also helps in managing high calcium levels caused by cancer by decreasing bone breakdown, which in turn reduces the release of calcium from the bones. Ultimately, Denub 60mg Injection contributes to making bones stronger and less susceptible to fractures.


To maximize the benefits of Denub 60mg Injection, it is essential to complement the treatment with a healthy lifestyle. Engaging in regular weight-bearing exercises, consuming foods rich in calcium and Vitamin D, and limiting alcohol and tobacco intake can further improve bone strength and overall health. Additionally, supplements of calcium and Vitamin D3 can enhance the effectiveness of Denub 60mg Injection in maintaining bone health.


How to use the Denub 60mg Injection

When it comes to using Denub 60mg Injection, it's important to follow your healthcare provider's guidance. This medicine should only be given to you by a doctor or nurse, so please do not try to administer it yourself. Denub 60mg Injection is typically administered by a healthcare professional to ensure safety and proper dosage. Remember, never self-administer this medication and always rely on trained medical staff for its administration. By following these instructions, you can ensure the safe and effective use of Denub 60mg Injection.


Uses of Denub 60mg Injection

Denub 60mg Injection is primarily used for the treatment of osteoporosis, a condition characterized by bone loss. It is also beneficial in addressing giant cell tumors of the bone and managing high levels of calcium in the body. By administering Denub 60mg Injection, healthcare providers can effectively help patients suffering from these conditions to improve their bone health and address related symptoms.


What conditions Denub 60mg Injection treats?

Osteoporosis is a bone disease that causes bones to become weak and thin due to decreased bone density. This condition is more common in postmenopausal women, as the decline in estrogen production after menopause leads to bone loss and increased fracture risk. However, osteoporosis can also affect men with aging or low testosterone levels. Symptoms may include back pain from fractured vertebrae, gradual height loss, stooped posture, and bones fracturing easily.


Should you consult a doctor?

Seek a doctor if you experience persistent or worsening side effects of Denub 60mg Injection such as musculoskeletal pain, pain in extremities, nerve pain, constipation, rash, or headache. It is crucial to consult your healthcare provider if any of these symptoms do not improve over time or if you are concerned about them. Additionally, inform your doctor about all the medications you are currently taking before starting Denub 60mg Injection. It is advisable for pregnant or breastfeeding individuals to consult with their doctors before using this medication to ensure its safety. Prioritize regular intake of the injection as directed by your doctor and accompany it with sufficient calcium and vitamin D supplements for optimal efficacy in managing osteoporosis and reducing fracture risk. Remember to complete the prescribed dose even if you start feeling better.


Side effects of Denub 60mg Injection

When taking Denub 60mg Injection, some side effects may occur, which typically do not require medical intervention as they tend to fade as your body gets used to the medication. However, consulting your doctor is advisable if these side effects persist or cause concern. Common musculoskeletal side effects include bone, muscle, or joint pain as well as pain in the extremities such as arms or legs. Nerve pain, abdominal discomfort, and constipation are also reported side effects. Some individuals may experience painful or frequent urination, rash, upper respiratory tract infections, eczema, or even hair loss while using this injection. If you notice any of these side effects, it is important to discuss them with your healthcare provider for proper management.


Safety advice

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liver

When using Denub 60mg Injection, it is important to be cautious if you have severe liver disease. Patients with liver issues may require a dose adjustment for this injection, so consulting your doctor is essential. If you have liver impairment or any concerns about your liver health, it is recommended to seek advice from your healthcare provider before using Denub 60mg Injection.

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kidney

Denub 60mg Injection requires caution in severe kidney disease. Adjustments in dosage may be necessary. Consult your doctor if you have kidney issues or concerns about using Denub 60mg Injection.

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alcohol

Caution is recommended when drinking alcohol while using Denub 60mg Injection. It is advisable to consult your doctor regarding any potential interactions.

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driving

Denub 60mg Injection typically does not impact your driving ability. It is advised to drive or handle machinery only when fully alert after taking Denub 60mg Injection.

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pregnancy

Denub 60mg Injection is not safe to use during pregnancy, as it can harm the developing baby. If you are a woman who can bear children, ensure to use effective birth control during treatment and for 5 months after stopping Denub 60mg Injection. Notify your doctor if you are pregnant or planning pregnancy.

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breastfeeding

Denub 60mg Injection is likely unsafe to use during breastfeeding as it may pass into the breastmilk and harm the baby, based on limited human data. Consult your doctor to determine if it is safe for breastfeeding mothers to use Denub 60mg Injection.


Consumption warning before consuming Denub 60mg Injection

Before using Denub 60mg Injection, please do not proceed if you are allergic to any of its ingredients or if you have low calcium levels in your blood. Inform your healthcare provider if you have conditions such as low calcium levels, kidney or liver issues, gum problems, weak immune system, or malabsorption. Additionally, notify your doctor if you have hypoparathyroidism, latex allergy, undergone thyroid surgery, have planned dental procedures, are taking glucocorticoids, or are unable to take calcium and vitamin D supplements. It is important to avoid using Denub 60mg Injection if you are pregnant, and consult your doctor if you are breastfeeding. Please note that this medication is not recommended for individuals under 18 years old due to the lack of established safety and effectiveness in this age group.


Disease interactions

When considering the use of Denub 60mg Injection, it is important to inform your doctor if you have hypocalcaemia, which is low levels of calcium in the blood, or immunosuppression. These conditions may interact with the medication and could require special considerations or adjustments to your treatment plan. It is essential to provide this information to your healthcare provider to ensure the safe and effective use of Denub 60mg Injection.


What if you forgot to take Denub 60mg Injection?

If you happen to miss a dose of Denub 60mg Injection, it is important to consult with your doctor promptly. It is crucial to keep up with the prescribed schedule to ensure optimal effectiveness of the medication. Your doctor can provide guidance on how to proceed if you have missed a dose of Denub 60mg Injection. Keeping open communication with your healthcare provider is key in managing your treatment plan effectively.


Related lab tests

When taking Denub 60mg Injection, it is important to monitor your calcium levels through lab tests. Calcium is a crucial mineral in the body that plays a key role in bone health, muscle function, and nerve transmission. Lab tests that are commonly recommended to check calcium levels include:


1. Total Calcium Test: This test measures the total amount of calcium in the blood, which includes both bound and free calcium.


2. Ionized Calcium Test: This test specifically measures the level of free calcium in the blood, which is the biologically active form of calcium.


3. Serum Parathyroid Hormone (PTH) Test: This test measures the level of parathyroid hormone in the blood, which helps regulate calcium levels in the body.


4. Vitamin D Test: Vitamin D is essential for calcium absorption, so checking vitamin D levels can provide additional information about calcium metabolism.


These lab tests help healthcare providers assess your calcium status and ensure that you are maintaining healthy levels while using Denub 60mg Injection. Regular monitoring of calcium levels is important to prevent any potential complications related to calcium imbalance.


Additional Information

Habit FormingNo
Chemical ClassMonoclonal Antibody
Therapeutic ClassPAIN ANALGESICS
Action Class-

FAQs


Disclaimer

The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.

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Dr. Gowri Kulkarni

MBBS - General Medicine, DNB - Psychiatry, MRCGP [INT] Family Medicine, BSIC (BACP)

Last update on 18-Nov-2024