Defrijet 500 Tablet
By Defrijet
Rx
10 Tablet in a Strip

Composition
Deferasirox(500mg)

Manufacturer - Sun Pharmaceutical Industries Ltd
Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

Expires on or after
September, 2026
About Defrijet 500 Tablet
Defrijet 500 Tablet is a medication used to treat chronic iron overload that can result from frequent blood transfusions. This condition occurs when the body accumulates an excessive amount of iron, which can lead to damage in various organs. Defrijet 500 Tablet contains the active ingredient deferasirox, which is classified as an iron chelator. It works by binding with the excess iron in the body and eliminating it through the feces, thereby reducing the risk of organ damage.
It is recommended to take Defrijet 500 Tablet on an empty stomach and at a consistent time each day to ensure optimal effectiveness. Following the prescribed dosage and duration is crucial for obtaining the maximum benefit from the medication. Common side effects of Defrijet 500 Tablet may include nausea, headache, constipation, diarrhea, and increased liver enzyme levels. If these side effects persist or worsen, it is important to inform your doctor promptly.
This medication is specifically indicated for the treatment of chronic iron overload resulting from blood transfusions in patients of varying age groups. Defrijet 500 Tablet can be used in patients two years and older with transfusional hemosiderosis, as well as in patients ten years and older with non-transfusion-dependent thalassemia (NTDT). However, it is essential to consult with your doctor before using Defrijet 500 Tablet, especially if you have kidney or liver diseases or if you are taking other medications.
Moreover, individuals with certain medical conditions such as moderate to severe kidney disease, severe liver disease, advanced myelodysplastic syndrome, and some types of cancer may not be suitable candidates for Defrijet 500 Tablet. Pregnant or breastfeeding women should use this medication only if advised by a doctor, and it is not recommended for children under two years of age.
While using Defrijet 500 Tablet, patients may experience side effects such as nausea, vomiting, diarrhea, abdominal pain, bloating, constipation, skin rashes, itching, headache, and changes in liver or kidney function tests. Monitoring these side effects and reporting any worsening symptoms to your healthcare provider is important for proper management of your condition. Regular monitoring of kidney and liver function may also be necessary during treatment with Defrijet 500 Tablet.
Benefits
Defrijet 500 Tablet offers significant benefits in the treatment of iron overload, a condition characterized by an excessive amount of iron in the body. This excess iron can be harmful, potentially leading to serious organ damage and various health complications such as cancer, irregular heartbeat, and liver cirrhosis. Symptoms of iron overload can manifest as high blood sugar levels, skin darkening, abnormal heart rhythms, and arthritis.
By utilizing the active component Deferasirox in Defrijet 500 Tablet, the excess iron is effectively targeted and removed from the body through stools. Deferasirox acts as a chelating agent, specifically binding to trivalent iron and facilitating its excretion. This mechanism helps to reduce the iron levels in the body to safe limits, thus mitigating the risk of organ damage and preventing further complications associated with iron overload.
It is crucial to follow the prescribed dosage of Defrijet 500 Tablet as directed by a healthcare provider to ensure optimal results and maximize the benefits of this medication. By effectively reducing excess iron in the body, Defrijet 500 Tablet plays a key role in safeguarding against the potential dangers of iron overload and promoting overall health and well-being.
How to use the Defrijet 500 Tablet
To properly use Defrijet 500 Tablet, follow the instructions provided by your doctor. Swallow the tablet as a whole with a glass of water. It is important not to chew, crush, or break the tablet before swallowing it. Take Defrijet 500 Tablet on an empty stomach as directed by your physician. The dosage and duration of treatment will be determined by your doctor based on factors such as your age, body weight, and the specific disease condition being treated. Adhering to these guidelines will help ensure the effectiveness of the medication in managing your condition. If you have any questions or concerns about how to use Defrijet 500 Tablet, consult your healthcare provider for further clarification.
Uses of Defrijet 500 Tablet
Defrijet 500 Tablet is used for treating chronic iron overload caused by blood transfusions in patients aged 2 years and older (transfusional hemosiderosis). It also helps in managing chronic iron overload in patients aged 10 years and older with non-transfusion-dependent thalassemia (NTDT). This medication is crucial for individuals facing these conditions to help regulate their iron levels effectively.
What conditions Defrijet 500 Tablet treats?
Defrijet 500 Tablet is used to treat hemochromatosis, a condition where the body has excess iron stored, leading to potential harm to organs like the heart, liver, and pancreas.
Should you consult a doctor?
It is important to seek medical advice before using Defrijet 500 Tablet if you are in an advanced stage of myelodysplastic syndrome, have advanced cancer, poor performance status, or severe thrombocytopenia. Additionally, inform your doctor if you have low levels of white blood cells, worsening anaemia, pancytopenia, or bone marrow failure. Seek immediate medical attention if you experience blurred vision, decreased hearing, diarrhea, vomiting, gastrointestinal ulcers, or hemorrhages while taking Defrijet 500 Tablet. These symptoms may require prompt evaluation and management by a healthcare professional to ensure your safety and well-being.
Side effects of Defrijet 500 Tablet
Defrijet 500 Tablet may cause some side effects, which usually go away as your body gets used to the medicine. Common side effects include nausea, headache, vomiting, rash, abdominal pain, constipation, itching, increased liver enzymes, abdominal distension, and diarrhea. In some cases, you may also experience dizziness, fever, sore throat, swelling of the arms or legs, change in skin color, anxiety, sleep disorders, and tiredness. It is important to note that if you encounter severe allergic reactions such as skin rash, blistering, high fever, flu-like symptoms, and difficulty breathing, you should stop taking Defrijet 500 Tablet and seek medical attention right away.
Other serious side effects that require immediate medical attention include decreased urine output, signs of liver problems like drowsiness and yellowing of the skin or eyes, high levels of ammonia in the blood leading to changes in brain function, vomiting blood or black stools, severe abdominal pain, frequent heartburn, partial loss of vision, severe upper stomach pain, blurred or cloudy eyesight, reduced hearing, and gastrointestinal issues like bloating, constipation, and indigestion. If you experience any of these severe side effects, it is crucial to stop the medication and contact your healthcare provider as soon as possible.
Safety advice

liver
Defrijet 500 Tablet should be used carefully in individuals with liver disease. It may be necessary to adjust the dosage of Defrijet 500 Tablet in such cases. It is important to consult with your doctor before using this medication, as there is limited information available on its use in patients with liver issues.

kidney
Defrijet 500 Tablet should be avoided in patients with kidney disease due to safety concerns. Consult your doctor before use.

alcohol
Consult your doctor when consuming alcohol with Defrijet 500 Tablet.

driving
Defrijet 500 Tablet may cause drowsiness, reduced alertness, or blurred vision. It is advisable to avoid driving if experiencing these side effects to ensure safety on the road.

pregnancy
Defrijet 500 Tablet should be avoided during pregnancy as animal studies suggest potential harm to the developing baby. Consult your doctor for a careful evaluation of benefits and risks before using this medication.

breastfeeding
Defrijet 500 Tablet is considered safe during breastfeeding. Limited data indicates no significant risk to the baby.
Age above 75(Geriatrics)
Age below 6 months(Pediatrics)
Consumption warning before consuming Defrijet 500 Tablet
Before taking Defrijet 500 Tablet, do not forget that if you have an allergy to the tablet or its components, this medicine is not for you. For pregnant or nursing women, it is generally not recommended due to inadequate safety information. Yet, your healthcare provider may decide to prescribe it if they believe the benefits outweigh the risks. Moreover, it is uncertain whether Defrijet 500 Tablet affects driving ability. So, be vigilant and avoid driving or using machinery if you have symptoms that impair concentration or reflexes. Seek immediate medical help if these symptoms persist. Alcohol consumption while on Defrijet 500 Tablet may result in adverse effects. Keep a close check on elderly and pediatric patients to prevent any potential toxicity risks.
Disease interactions
Individuals experiencing bone marrow suppression, dermatologic toxicities, hepatic impairment, renal dysfunction, auditory and ocular abnormalities, as well as gastrointestinal complications are advised to seek medical advice prior to consuming Defrijet 500 Tablet. It is crucial for patients with these underlying conditions to consult with a healthcare professional to ensure the medication's safety and effectiveness. By discussing these health concerns with a doctor, potential drug interactions can be properly assessed and managed, leading to a better understanding of how Desirox 500 mg Tablet may impact the individual based on their specific health status.
What if you forgot to take Defrijet 500 Tablet?
If you forget to take a dose of Defrijet 500 Tablet, try to take it as soon as you remember. But if it's close to the time for your next scheduled dose, just skip the missed one. It's important not to double up on doses to make up for the missed one. Stick to your regular dosing schedule to ensure the medication works effectively.
What happens if you take overdose of Defrijet 500 Tablet?
If you or someone has taken an excessive amount of Defrijet 500 Tablet by mistake, it is essential to seek immediate medical help from a doctor or go to a nearby hospital. Overdosing on Defrijet 500 Tablet can lead to symptoms such as nausea, vomiting, abdominal pain, diarrhea, and potential complications affecting the kidneys or liver. It is crucial to address any overdose situation promptly to receive appropriate medical attention and care.
Related lab tests
Related Lab Tests for monitoring while taking Defrijet 500 Tablet include Iron Serum, Iron Studies, and Total Iron Binding Capacity. These tests help in assessing the levels of iron in the body and ensuring the medication is working effectively. Additionally, it is recommended to monitor Urine Routine & Microscopy to check for any signs of abnormalities in the urine. Bilirubin Profile is essential for evaluating liver health, while Kidney Function Test (KFT) and Liver Function Test (LFT) can provide insights into kidney and liver function respectively. Monitoring Creatinine, Serum, Uric Acid, Serum, Albumin, Serum, Alkaline Phosphatase, Serum, Bilirubin Direct, Serum, and Bilirubin Total, Serum can also help in assessing overall health and potential side effects of the medication. It is important to regularly perform these lab tests as advised by the healthcare provider while undergoing treatment with Defrijet 500 Tablet.
Additional Information
Habit Forming | No |
Chemical Class | Triazole & benzoate derivative |
Therapeutic Class | - |
Action Class | Iron chelating agents |
FAQs
Disclaimer
The information provided on this website is to the best of our abilities to ensure it is accurate, reliable, and reviewed by a team of professionals. It should not be used to diagnose, prevent, or cure any health problem. The information presented here is not intended to create a doctor-patient relationship or replace a registered medical practitioner's advice, diagnosis, or treatment. The absence or provision of any information or warning regarding any medicine should not be assumed as an implied or explicit assurance of safety or efficacy. We highly recommend consulting your registered medical practitioner for all queries or doubts related to your medical condition. Do not ignore professional medical advice or delay seeking it based on the content encountered on our website. We intend to support, not replace, the doctor-patient relationship.
₹402.65
Inclusive of all taxes
Content verified by

Dr. Archana Prabhakar
MBBS, M.Med (Family Medicine)
Last update on 01-Oct-2024